Distribution of haptoglobin phenotypes in oesophageal and gastric cancer.
نویسندگان
چکیده
Haptoglobin (Hp) phenotypes were studied in 72 oesophageal and 104 gastric cancer patients and compared with 100 healthy controls to see if there is any association between oesophageal and gastric cancer and haptoglobin type. There was a significantly increased frequency of Hp 2-1 (59.7%) and Hp 2-2 (91.3%) in oesophageal and gastric cancer patients. Our results suggest that genetic factors play a role in the aetiology and pathogenesis of gastrointestinal tract malignancy.
منابع مشابه
Association of Haptoglobin Phenotypes with Serum Levels of IgE and IgA in Allergic Rhinitis Patients
Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels ...
متن کاملDetermination of Haptoglobin Genotype in an Iranian Population with Idiopathic Generalized Epilepsy
Background: Haptoglobin (Hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. Haptoglobin expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or...
متن کاملDistribution of Haptoglobin Phenotypes among Patients with Different Types of Cancer in Sudan
In this study we aimed to find possible correlation between varying cancer types and haptoglobin phenotypes Hp1-1, Hp2-1 and Hp2-2. Haptoglobin (Hp) phenotypes among patients with different types of cancer in Sudan were detected by polyacrylamide gel electrophoresis followed by benzidine staining of the gels. The results indicated that individuals with Hp1-1 phenotype were significantly higher ...
متن کاملOesophageal and gastric gongylonemiasis in a donkey
Members of the genus Gongylonema are nematodes that commonly infect ruminants, particularly sheep and goats. An 11-year-old donkey mare was referred to the Veterinary Teaching Hospital, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, northeastern Iran, with a history of acute colitis. At post-mortem examination, there were several white to pink zigzag tracks in the muco...
متن کاملThe Association Between C194T and G399A Polymorphism of XRCC1 Gene and Susceptibility to Gastric Cancer in the People Living in the Western Part of Iran
Background: Gastric cancer is one of the most common malignancies in the world. It may result from a defect in the genes involved in DNA repair. One of the essential genes in the repair pathway is the XRCC1 gene that its polymorphisms in the human population play a role in gastric cancer susceptibility. The main purpose of this study was to investigate the association of 194C/T and 399G/A polym...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of medical genetics
دوره 26 3 شماره
صفحات -
تاریخ انتشار 1989